Research Staff

Mohamed received his BSc and MSc degrees in Biochemistry from Ain Shams University (Egypt) followed by a PhD in Chemistry from the University of Manchester (UK). Mohamed is an accomplished synthetic biologist with a wealth of transferable skills acquired in both academic and industrial sectors. He has a proven track record of success in developing sustainability strategies for entire process cycles of using microbial cell factories for industrial applications, starting from performing biocatalytic assays, constructing novel enzymatic cascade pathways, and genome engineering of various bioproduction platforms in E. coli and other non-model organism chassis. Furthermore, Mohamed has experience in developing fermentation media and conditions, downstream processing (DSP) of several bioproducts, and continuous support to both pilot- and large-scale production stages for enhancing decision-making processes in the bio-based industrial and commercial phases

Marijan received his MSc degree in Biochemical Engineering and Biotechnology from the University of Belgrade (Serbia) in 2013, and a PhD degree in Biotechnology from the University of Ljubljana (Slovenia) in 2017. During his doctoral studies at the Microprocess Engineering Research Group (University of Ljubljana), he developed miniaturized packed-bed reactors with immobilized enzymes. From 2017 to 2019, Marijan was a Postdoctoral Research Associate at the Department of Catalysis and Chemical Reaction Engineering (National Institute of Chemistry, Ljubljana, Slovenia). His research focus within the Future BRH will be on the development and characterization of microreactors for continuous enzymatic synthesis.

Matthew graduated with an MSci in biochemistry from the University of Birmingham (UK) in 2014 and with his PhD from the University of Liverpool (UK) in 2018. During his Masters Matthew studied the impacts of nitrosative stress on Delsulfovibrio desulfuricans with Prof Jeff Cole in the Institute of Microbiology and Infection. His PhD focussed on the cyanobacterial carbon fixation machinery and carboxysome structure, function and biophysical properties using atomic force microscopy. From 2018 to 2021 Matthew was a postdoctoral research associate in Prof Nigel Scrutton’s group at the Manchester Institute of Biotechnology. This postdoctoral role involved the study of terpene production. Within Future BRH he is developing novel routes to biological carbon capture utilisation and storage using photosynthetic bacteria.

Azar completed her undergraduate and Masters qualifications in Chemical Engineering, followed by her PhD in organic and macromolecular chemistry at the University of Lille, France. The main focus of her thesis work was flow chemistry and process intensification, as well as kinetics, thermodynamics, and organic synthesis. Azar is a global researcher with a global network of collaborators; she has worked as a research fellow in laboratories in France, Brazil, Norway, China, Czech Republic and the UK. Azar’s expertise spans a broad range of topics in chemical engineering and chemistry.

Toby received a first class degree in Biochemistry and was awarded a PhD in Biophysical Chemistry from the University of Manchester in 2016. During his postgraduate studies, he investigated the catalytic mechanism of the diflavin oxidoreductases family of enzymes, developing novel methods to examine redox-linked protein domain dynamics. From 2016, Toby was a postdoctoral research associate at the University of Manchester, studying the role of redox partner tethering in enzyme catalysis and contributing his expertise in Enzymology to many research projects within the MIB. Toby is a multifaceted scientist with interests in mechanistic enzymology, biophysics, protein engineering and spectroscopic assay development. Within the Future BRH, he will focus on the development of industrial biocatalysts and high throughput assays to study enzyme turnover.

Chatchai obtained his PhD in Chemical Biology from Chulabhorn Graduate Institute (CGI), Chulabhorn Royal Academy, Thailand. Chatchai then joined the Chulabhorn Research Institute (CRI), Thailand, as a postdoctoral associate working on medicinal plant natural products and investigating their biological activity, and synthesis of water-soluble betaine dyes of C3 quinolinium derivatives. Chatchai continued his postdoctoral study at Vidyasirimedhi Institute of Science and Technology (VISTEC), Thailand, working on synthetic biology aiming to produce value-added chemicals from organic waste, demonstrating scaling-up approaches for microbial cultivation and large-scale microbial fermentation. Within Future BRH Chatchai is focused on microbial fermentation at lab scale with a view to scale up and sustainable process engineering for biomanufacturing.

Nicole Leferink is an experienced research scientist with a background in biochemistry and biotechnology. She obtained a BSc degree from the Saxion University of Applied Sciences followed by an MSc and PhD degree from Wageningen University in the Netherlands. For her postdoctoral research she joined the molecular enzymology group of Prof. Nigel Scrutton at the Manchester Institute of Biotechnology. Nicole’s main research interests are rational engineering and directed evolution towards the development of designer enzyme activities for applications. Nicole has experience in enzyme discovery, characterisation, and engineering, high-throughput screening, laboratory automation, and biomanufacturing using synthetic biology.

Hanan is an experienced researcher who obtained her BSc in pharmaceutical sciences and MSc in biochemistry. She then received a scholarship to study a PhD in the UK. Hanan obtained her PhD in biochemistry from the University of Leicester under the supervision of Professor Nigel Scrutton studying the mechanism of the morphinone reductase enzyme. She worked as a postdoctoral research associate at the University of Leicester and at the Manchester Institute of Biotechnology before joining the Future BRH. Hanan has worked in diverse research projects and has developed a broad range of experience in biocatalysis, synthetic biology & metabolic engineering, downstream processing, enzymology, biophysics, systems biology, analytical & organic and polymer chemistry. She also worked with industrial partners to develop novel biomanufacturing processes. Hanan is keen to contribute to the aspirations of the Future BRH in supporting the growing bioeconomy and her role involves the development of robust sustainable bio-routes to biomaterials, biofuel, key intermediates and chemicals for various industrial applications.

Aled has a broad academic background spanning chemistry, materials engineering and synthetic biology. Specialising in interdisciplinary research, he hopes to bridge the gap between synthetic biology and other disciplines – such as materials science, polymer chemistry and bio-medical materials. After obtaining his MChem degree at the University of Liverpool, Aled undertook a PhD in Materials Chemistry jointly at the University of Liverpool and at the Institute of Materials Research and Engineering (IMRE) in Singapore. Following this, he was a postdoctoral researcher at the University of Manchester where he worked on several projects at the interface of materials science and synthetic biology.

Mauro has a wide background in plant science, microbiology, genetics, and biotechnology that he puts together in an integrated approach to biomanufacturing. He received his BSc in Molecular Biology from the University of Buenos Aires and his PhD in Biochemistry and Cell Biology from Rice University, Houston TX, and was a Postdoctoral Research Associate at the University of York and The University of Manchester. He has specialised in metabolic optimisation through strain engineering towards high titres and utilisation of renewable carbon feedstocks such as waste lignocellulose. His current research focus is metabolic engineering through directed evolution and improving tolerance to intermediate and end-product toxicity in production hosts through synthetic biology.

Chris studied Biochemistry and Molecular Biology in Manchester before earning his PhD at the Paterson Institute for Cancer Research. He then worked as a postdoc at the Paterson, studying the interactions of cell surface glycosaminoglycans with growth factors and their receptors. Chris continued his post-doctoral studies at the Manchester Institute of Biotechnology, engineering riboswitches as novel gene regulatory tools. In 2015, he joined SYNBIOCHEM (the Manchester synthetic biology research centre) as an experimental officer, helping to develop an automated design-build-test-learn pipeline. His current research involves the construction of biosynthetic pathways and engineering microbial host strains for the production of diverse small molecule targets, including material monomers and plant-derived alkaloids and flavonoids as active pharmaceutical ingredients. In 2022 he joined the Future BRH as a Research Fellow to continue this work.

Matt is an analytical biochemist specialising in quantitative protein mass spectrometry.  He has an undergraduate masters degree in chemistry from the University of St Andrews and a PhD in Biochemistry from the University of Cambridge focusing on quantitative proteomics. After completing his PhD Matt worked in industry for LGC working on methods to quantify host cell contaminants in biologic medicines before returning to academic research with two postdoctoral research associate positions at the University of Manchester. In the first project Matt quantified expression of drug transporter and metabolising proteins in human gut and liver tissues to inform systems biology models to predict drug metabolism and pharmacokinetics. In the second project Matt quantified proteins expression in human serum samples to identify potential biomarkers for ovarian cancer. At Future BRH Matt is working on analytical methods to quantify enzyme expression in host strains.

Viranga obtained her B.Sc in Microbiology from University of Pune, India, and Masters in Biotechnology from University of Peradeniya, Sri Lanka. She joined The University of Manchester as a Research Technician in 2010 and has worked with several groups across a range of areas including microbiology, molecular biology and tissue culture. Viranga’s current role is to support the overall delivery of the Future BRH research programme and provide coordination of laboratory health and safety and procurement. She works alongside the Future BRH Project Manager to ensure smooth day to day research operation of the Hub.

Helen is an experienced research scientist specialising in enzymology, biotechnology and synthetic biology. She obtained her PhD degree in the biochemistry of extremophile enzymes at the University of Waikato in New Zealand. Prior postdoctoral research positions were undertaken at Yale University, University of Leicester, Exeter University and more recently at the University of Manchester. Additional skills developed during prior research include  protein crystallography, robotic laboratory automation, analytical (bio)chemistry, molecular biology and synthetic biology. Helen’s main research focus is the development of commercially viable synthetic biology routes to biofuels and other biochemicals using microorganisms as ‘microbial chassis.’ This encompasses de novo enzymatic pathway design through to laboratory scale fermentation of microbial biorefineries.

Joe received a BSc(Hons) in microbiology from the University of Sheffield before completing a PhD in biotechnology at the University of Nottingham. His first postdoc was at the Synthetic Biology Research Centre at the University of Nottingham before moving to the Department of Molecular Biology and Biotechnology at the University of Sheffield. Joe’s projects have all focused on metabolic engineering of microbial chassis to produce industrially relevant chemicals at high titre. He hopes to bring these skills to the Future BRH where he will focus on developing microbial strains for the bioproduction of various chemicals.

Jonathan received his BSc in Natural Sciences and MSc in Industrial and Commercial Biotechnology from the University of Newcastle. He then moved to the University of Manchester to complete his PhD under the supervision of Prof. Nigel Scrutton, in the Manchester Institute of Biotechnology. His PhD research explored the development and application of single domain antibodies as tools for synthetic biology, with specific applications for the modulation of monoterpenoid production in E. coli. Prior to joining the Future BRH team, he took up a postdoctoral research associate position in the Scrutton Lab exploring similar themes. Jonathan’s research interests include metabolic engineering and the application of ‘Design of Experiments’ for the development of microbial cell factories.